THE CHANGING ECONOMIC SPATIAL STRUCTURE OF EUROPE

Many theoretical and practical works aim at describing the spatial structure of Europe, where spatial relations have undergone continuous change. This article gives an overview of models describing the spatial structure of Europe. Their diversity is highlighted by listing of these models, without any claim to completeness. Our study aims at describing the economic spatial structure of Europe with bi-dimensional regression analysis based on the gravitational model. With the help of the gravity model, we get a spatial image of the spatial structure of Europe. With these images, we can justify the appropriateness of the models based on different methodological backgrounds by comparing them with our results. Our goal is not to create and show a new model that overwrites the existing ones, but rather to contribute to understanding the European spatial structure through a new methodological approach

Effect of late spring frost event on nutrition aspects of a sour cherry orchard in East Hungary

Similarly to 2007, 2011 was also critical year for fruit growers in Eastern-Hungary. Serious frost damage was observed at lateblooming period (6 May (T=-1.6°C)) in this region, which caused approximately 60-65% of fruit loss.The aim of this study is to investigate the effects of a spring frost event on nutrient uptake and status of the trees of a sour cherry plantationat Újfehértó.The symptoms of frost were observed visually. This visual observation was confirmed by SPAD readings. The frost affected the macroandmicronutrient contents of leaves.It was found that the frost affected the nutrient uptake negatively, but the effect of it was not significantly sometimes. It can be stated thatthe nutrient demand of trees can be supplied only under even worse conditions

Effect of late spring frost event on nutrition aspects of a sour cherry orchard in East Hungary

Similarly to 2007, 2011 was also critical year for fruit growers in Eastern-Hungary. Serious frost damage was observed at late blooming period (6 May (T=-1.6°C)) in this region, which caused approximately 60-65% of fruit loss. The aim of this study is to investigate the effects of a spring frost event on nutrient uptake and status of the trees of a sour cherry plantation at Újfehértó. The symptoms of frost were observed visually. This visual observation was confirmed by SPAD readings. The frost affected the macroand micronutrient contents of leaves. It was found that the frost affected the nutrient uptake negatively, but the effect of it was not significantly sometimes. It can be stated that the nutrient demand of trees can be supplied only under even worse conditions

Importance of orchard floor management in organic fruit growing (nutritional aspects)

Worldwide research goals and concerns are to soil conservation and improve. This conception is mostly actual in horticulture where the numbers of high-density plantings are continuously increasing. High-density orchards cause more intensive nutrient and water uptake. So that the preservation of soil moisture and nutrient level are key factors in qualified fruit growing. On the other hand due to the climatic changes the water supply of trees will be satisfied among worse conditions than some decades ago. Appearance of water supply problems and water stress is increased in organic growing, where the number of corrections is limited anyway. Furthermore, floor management is a successful tool in weed management which causes many problems for organic growers due to the prohibition of synthetic herbicides. This paper will mainly focus on the nutritional aspects of methods of orchard floor management for growers adopting organic fruit management to make their production profitable

Importance of boron in fruit nutrition

Boron (B) is an essential micronutrient in plants especially in fruits. Despite of this fact there are very few information about itsapplication, uptake and symptoms in Hungarian fruit growing sector. Nowadays we should consider the effects of weather conditions on soilB availability increasingly according to the climatic anomalies. Identifying of internal and external symptoms of plant parts (leaf, fruit) is helpfor growers to recognize the deficiency and excess symptoms in time. Methods and application rates of boron fertilization provide furtherinformation for growers to achieve qualify-oriented fruit growing among Hungarian conditions. The aim of this minireview is to focus on theimportance of boron in fruit nutrition

Importance of orchard floor management in organic fruit growing (nutritional aspects)

Worldwide research goals and concerns are to soil conservation and improve. This conception is mostly actual in horticulturewhere the numbers of high-density plantings are continuously increasing. High-density orchards cause more intensive nutrient and wateruptake. So that the preservation of soil moisture and nutrient level are key factors in qualified fruit growing. On the other hand due to theclimatic changes the water supply of trees will be satisfied among worse conditions than some decades ago. Appearance of water supplyproblems and water stress is increased in organic growing, where the number of corrections is limited anyway. Furthermore, floormanagement is a successful tool in weed management which causes many problems for organic growers due to the prohibition of syntheticherbicides. This paper will mainly focus on the nutritional aspects of methods of orchard floor management for growers adopting organic fruitmanagement to make their production profitable

Antiviral, antimicrobial and antibiofilm activity of selenoesters and selenoanhydrides

Selenoesters and the selenium isostere of phthalic anhydride are bioactive selenium compounds with a reported promising activity in cancer, both due to their cytotoxicity and capacity to reverse multidrug resistance. Herein we evaluate the antiviral, the biofilm inhibitory, the antibacterial and the antifungal activities of these compounds. The selenoanhydride and 7 out of the 10 selenoesters were especially potent antiviral agents in Vero cells infected with herpes simplex virus-2 (HSV-2). In addition, the tested selenium derivatives showed interesting antibiofilm activity against Staphylococcus aureus and Salmonella enterica serovar Typhimurium, as well as a moderate antifungal activity in resistant strains of Candida spp. They were inactive against anaerobes, which may indicate that the mechanism of action of these derivatives depends on the presence of oxygen. The capacity to inhibit the bacterial biofilm can be of particular interest in the treatment of nosocomial infections and in the coating of surfaces of prostheses. Finally, the potent antiviral activity observed converts these selenium derivatives into promising antiviral agents with potential medical applications.

Selenocompounds as Novel Antibacterial Agents and Bacterial Efflux Pump Inhibitors

Bacterial multidrug resistance is becoming a growing problem for public health, due to the development and spreading of bacterial strains resistant to antimicrobials. In this study, the antibacterial and multidrug resistance reversing activity of a series of seleno-carbonyl compounds has been evaluated. The effects of eleven selenocompounds on bacterial growth were evaluated in Staphylococcus aureus, methicillin resistant S. aureus (MRSA), Enterococcus faecalis, Escherichia coli, and Chlamydia trachomatis D. The combination effect of compounds with antibiotics was examined by the minimum inhibitory concentration reduction assay. Their efflux pump (EP) inhibitory properties were assessed using real-time fluorimetry. Relative expressions of EP and quorum-sensing genes were studied by quantitative PCR. Results showed that a methylketone selenoester had remarkable antibacterial activity against Gram-positive bacteria and potentiated the activity of oxacillin in MRSA. Most of the selenocompounds showed significant anti-chlamydial effects. The selenoanhydride and the diselenodiester were active inhibitors of the AcrAB-TolC system. Based on these results it can be concluded that this group of selenocompounds can be attractive potential antibacterials and EP inhibitors. The discovery of new derivatives with a significant antibacterial activity as novel selenocompounds, is of high impact in the fight against resistant pathogen

Evidence for Plastic Processes in Migraine with Aura: A Diffusion Weighted MRI Study

Background: Formerly white matter abnormalities in a mixed group of migraine patients with and without aura were shown. Here, we aimed to explore white matter alterations in a homogeneous group of migraineurs with aura and to delineate possible relationships between white matter changes and clinical variables.Methods: Eighteen patients with aura, 25 migraine patients without aura and 28 controls were scanned on a 1.5T MRI scanner. Diffusivity parameters of the white matter were estimated and compared between patients’ groups and controls using whole-brain tract-based spatial statistics.Results: Decreased radial diffusivity (p < 0.036) was found bilaterally in the parieto-occipital white matter, the corpus callosum, and the cingular white matter of migraine with aura (MwA) patients compared to controls. Migraine without aura (MwoA) patients showed no alteration compared to controls. MwA compared to MwoA showed increased fractional anisotropy (p < 0.048) in the left parieto-occipital white matter. In MwA a negative correlation was found between axial diffusivity and disease duration in the left superior longitudinal fascicle (left parieto-occipital region) and in the left corticospinal tract (p < 0.036) and with the number of the attacks in the right superior longitudinal fascicle (p < 0.048).Conclusion: We showed for the first time that there are white matter microstructural differences between these two subgroups of migraine and hence it is important to handle the two groups separately in further researches. We propose that degenerative and maladaptive plastic changes coexist in the disease and the diffusion profile is a result of these processes